Psoriasis: Interplay between dysbiosis and host immune system

Area of Science:

• Dermatology and Microbiology
• Human Microbiome Research
• Immunology

Background:

• Psoriasis pathogenesis is increasingly linked to the gut and skin microbiota.
• Microbiome dysbiosis, marked by altered diversity, composition, and pathobiont proliferation, may trigger psoriasis flares.
• Gut dysbiosis can cause "leaky gut syndrome," leading to endotoxin translocation and systemic inflammation.

Purpose of the Study:

• To review the correlation between skin and gut microbiota dysbiosis and psoriasis.
• To discuss bacteriotherapeutic strategies for psoriasis management.

Main Methods:

• Literature review of studies on human microbiome and psoriasis.
• Exploration of mechanistic links between dysbiosis and psoriatic inflammation.
• Analysis of research on probiotics, prebiotics, metabiotics, and fecal microbiota transplantation (FMT) in psoriasis.

Main Results:

• Gut dysbiosis contributes to psoriasis via increased intestinal permeability and systemic inflammation.
• Skin dysbiosis disrupts cutaneous homeostasis, facilitating pathogen invasion and inflammation.
• Pruritus-induced scratching can exacerbate skin barrier disruption and inflammation.

Conclusions:

• Microbiome dysbiosis in both the gut and skin plays a significant role in psoriasis.
• Bacteriotherapy, including probiotics, prebiotics, metabiotics, and FMT, shows potential for psoriasis management.
• Targeting the microbiome offers a promising avenue for novel psoriasis treatment strategies.