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Changes in cardiorespiratory function during gastric lavage for drug overdose.
Human Toxicology
|May 1, 1987
Summary
Gastric lavage for self-poisoning significantly impacts cardiorespiratory function, increasing pulse rate and decreasing oxygen levels, especially in conscious smokers. Alternative methods like induced emesis may be safer.
Area of Science:
- Toxicology
- Cardiology
- Pulmonology
Background:
- Gastric lavage is a common procedure for managing self-poisoning.
- Potential cardiorespiratory effects of gastric lavage require further investigation.
Purpose of the Study:
- To assess the impact of gastric lavage on cardiorespiratory function in self-poisoning patients.
- To identify patient factors influencing these cardiorespiratory changes.
Main Methods:
- Studied 42 self-poisoning patients undergoing gastric lavage.
- Monitored cardiorespiratory function using electrocardiography and ear oximetry.
- Analyzed changes in pulse rate and partial pressure of oxygen.
Main Results:
- Mean pulse rate increased from 92 to 121 bpm; mean partial pressure of oxygen decreased from 95 to 80 mmHg (P < 0.001).
- Changes were more pronounced in conscious patients, smokers, and older males (≥45 years).
- Electrocardiograph abnormalities occurred in 41% of patients, with 2 experiencing serious changes.
Conclusions:
- Gastric lavage significantly affects cardiorespiratory function.
- Consideration should be given to alternative treatments like induced emesis or activated charcoal, especially for conscious, older, smoking patients.