Related Experiment Video

Updated: Sep 1, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Elevated Cardiac Troponin I following Asymptomatic Intradialytic Hypotension: A Pilot Study with a 2-Year Follow-Up

Toktam Alirezaei1, Mir Jafar Jebreil Moosavi1, Rana Irilouzadian2

  • 1Clinical Research Development Unit of Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

International Journal of Clinical Practice
|August 15, 2022
PubMed

Insights

Asymptomatic intradialytic hypotension (IDH) during hemodialysis (HD) is linked to increased cardiac troponin I (cTnI) levels in end-stage renal disease (ESRD) patients. Monitoring blood pressure during HD is crucial for predicting cardiac events.

Area of Science:

  • Nephrology
  • Cardiology
  • Clinical Medicine

Background:

  • Intradialytic hypotension (IDH) is a common complication in hemodialysis (HD) for end-stage renal disease (ESRD) patients.
  • The impact of asymptomatic IDH on cardiac troponin I (cTnI) levels remains unclear.

Purpose of the Study:

  • To investigate the association between asymptomatic IDH and elevated cTnI levels.
  • To evaluate the long-term cardiovascular outcomes in ESRD patients undergoing HD.

Main Methods:

  • 70 asymptomatic ESRD patients with negative predialysis cTnI were monitored during HD sessions.
  • Hemodynamic changes and symptoms were recorded.
  • Patients were followed for two years for acute coronary syndrome (ACS) and cardiac death.

Main Results:

  • Asymptomatic IDH was identified in 38.6% of patients based on 2007 guidelines.
  • A significant correlation was found between asymptomatic IDH and elevated postdialysis cTnI levels (r=0.492, p<0.05).
  • Patients with elevated cTnI experienced more ACS and cardiac death during follow-up.

Conclusions:

  • Asymptomatic IDH during HD significantly affects cTnI levels in ESRD patients.
  • Elevated cTnI, influenced by asymptomatic IDH, predicts adverse cardiovascular outcomes.
  • Monitoring blood pressure during HD is critical for managing cardiovascular risk in ESRD patients.
Abstract

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