Related Experiment Video
Updated: Sep 1, 2025

Optimizing Isolation and Purification of Murine Glomerular Mesangial Cells
Published on: March 7, 2025
Malignant juxtaglomerular cell tumor
Daniel Geisler1, Fawaz Almutairi1, Ivy John1
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Abstract:
Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity.
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