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Ionic liquid-based electroactive materials: a novel approach for cardiac tissue engineering strategies
R M Meira1,2, D M Correia1,3, A García Díez4
1Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, 4710-057 Braga, Portugal. cribeiro@fisica.uminho.pt.
Journal of Materials Chemistry. B
|August 15, 2022
Summary
New electroactive hybrid materials combining ionic liquids with P(VDF-TrFE) show promise for cardiac tissue engineering. These scaffolds enhance electrical conductivity and support cell growth, offering a viable option for regenerating cardiac tissue.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Materials Chemistry
Background:
- Cardiac tissue regeneration requires biomaterials that mimic the native microenvironment.
- Electroactive scaffolds are crucial for actively recreating this microenvironment.
- Ionic liquids (ILs) offer unique properties for advanced material development.
Purpose of the Study:
- To develop novel ionic electroactive IL/polymer hybrid materials for cardiac tissue engineering.
- To investigate the properties and potential of these hybrid materials as scaffolds.
- To evaluate their suitability for creating electroactive microenvironments in cardiac TE.
Main Methods:
- Hybrid materials were synthesized using poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) and two ionic liquids: [Ch][DHP] and [Ch][TFSI].
- Morphological, physico-chemical, thermal, and electrical properties were characterized.
- Cytotoxicity assays and cell adhesion/proliferation studies using H9c2 myoblasts were performed.
Main Results:
- IL incorporation altered surface topography, roughness, and wettability.
- Surface and volume electrical conductivities significantly increased.
- Hybrid materials showed stability after UV sterilization but reduced conductivity after PBS washing.
- ILs acted as defects in the P(VDF-TrFE) crystallization process.
- [Ch][DHP]-based films were non-cytotoxic and supported H9c2 cell adhesion and proliferation.
Conclusions:
- Ionic electroactive IL/polymer hybrid materials offer tunable electrical properties for cardiac tissue engineering.
- [Ch][DHP]-based materials are biocompatible and promote cell growth, indicating strong potential for cardiac TE applications.
- These advanced materials can facilitate the creation of electroactive microenvironments for tissue regeneration.
