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Antimicrobial surface processing of polymethyl methacrylate denture base resin using a novel silica-based coating
Chiaki Tsutsumi-Arai1, Kazuhiro Akutsu-Suyama2, Yoko Iwamiya3
1Department of Oral Medicine and Stomatology, School of Dental Medicine, Tsurumi University, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama, Kanagawa, 230-8501, Japan. tsutsumi-c@tsurumi-u.ac.jp.
Clinical Oral Investigations
|August 15, 2022
Summary
A new silica-based denture coating containing hinokitiol effectively inhibits Candida albicans growth and adhesion. This novel antifungal coating shows promise for treating denture stomatitis.
Area of Science:
- Biomaterials Science
- Oral Microbiology
- Nanotechnology
Background:
- Denture stomatitis, often caused by Candida albicans, is a common complication for denture wearers.
- Current treatments for denture stomatitis can be limited in efficacy and may have side effects.
- Developing novel antifungal agents for denture surfaces is crucial for improving oral health.
Purpose of the Study:
- To investigate the surface characteristics of a novel silica-based denture coating incorporating hinokitiol.
- To evaluate the efficacy of this hinokitiol-containing coating in inhibiting Candida albicans adhesion and growth on denture base resins.
Main Methods:
- Preparation of silica-based coating solutions with and without hinokitiol.
- Assessment of Candida albicans biofilm formation on coated and uncoated denture specimens using CFU assay, fluorescence microscopy, and SEM.
- Surface analysis including roughness, wettability, FT-IR, and 1H NMR.
- Evaluation of coating stability after water immersion.
Main Results:
- Coated specimens, particularly those with hinokitiol, showed significantly reduced Candida albicans colony-forming units (CFUs).
- SEM and fluorescence microscopy confirmed reduced fungal presence and increased cell death on hinokitiol-coated surfaces.
- Coating resulted in reduced surface roughness and increased hydrophobicity, with successful incorporation of hinokitiol confirmed by FT-IR and 1H NMR.
Conclusions:
- A novel silica-based denture coating incorporating hinokitiol effectively inhibits Candida albicans growth on denture surfaces.
- This antifungal coating represents a promising new therapeutic option for managing denture stomatitis.
