Related Experiment Video
Updated: Sep 1, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
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COVID-19: Acing the Treatment
Jez Hunter1, Puskar Bura2, Richard King2
1Department of Anaesthetics and Intensive Care Medicine, Royal Cornwall Hospital, Treliske, Truro, UK.
Summary
Angiotensin converting enzyme 2 (ACE2) is crucial for SARS-CoV-2 cell entry, potentially worsening lung injury. However, ACE2-targeting therapies may offer survival benefits in COVID-19 patients.
Area of Science:
- Cardiovascular Science
- Infectious Disease
- Pulmonology
Background:
- SARS-CoV-2 utilizes Angiotensin Converting Enzyme 2 (ACE2) as its cellular receptor, triggering inflammatory responses and acute lung injury.
- The Renin-Angiotensin-Aldosterone System (RAAS) plays a complex role in COVID-19, with potential for both detrimental and beneficial effects.
- Early concerns about ACE inhibitors (ACEi) and Angiotensin Receptor Blockers (ARBs) in COVID-19 have been scientifically refuted.
Discussion:
- ACEi and ARBs may provide a survival advantage for patients with COVID-19.
- Understanding the intricate mechanisms of the RAAS in viral infections is critical for therapeutic development.
- The biological plausibility of RAAS modulation warrants further investigation for novel treatment strategies.
Key Insights:
- ACE2 is the key entry point for SARS-CoV-2 into host cells.
- RAAS-modulating drugs like ACEi and ARBs show potential therapeutic benefits in COVID-19.
- Continued research into RAAS pathways is essential for managing viral pandemics.
Outlook:
- Developing new treatments targeting the ACE2-SARS-CoV-2 interaction is crucial.
- Future research should focus on the long-term implications of RAAS modulation in viral infections.
- Proactive strategies are needed to combat emerging variants and future pandemic waves.
Keywords:
Angiotensin II receptor blockersAngiotensin converting enzyme inhibitorsCOVID-19Novel treatmentsRenin-angiotensin-aldosterone systemMore Related Videos
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