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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Updated: Sep 1, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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A Primer on Radiopharmaceutical Therapy.

Kilian E Salerno1, Soumyajit Roy2, Cathy Ribaudo3

  • 1Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

International Journal of Radiation Oncology, Biology, Physics
|August 15, 2022
PubMed
Summary

This primer introduces radiation oncologists to radiopharmaceutical therapy (RPT). It covers RPT definitions, indications, and regulatory aspects, highlighting its collaborative potential in cancer care.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Radiation oncologists possess expertise in therapeutic radiation and oncology.
  • Radiopharmaceutical therapy (RPT) offers a novel approach integrating these skills.
  • Collaboration with nuclear medicine and medical oncology is key for RPT implementation.

Purpose of the Study:

  • To provide a foundational understanding of RPT for US-based radiation oncologists.
  • To review current and emerging indications for RPT.
  • To discuss regulatory considerations for integrating RPT into clinical practice.

Main Methods:

  • Literature review of RPT data and clinical applications.
  • Analysis of regulatory pathways for radiopharmaceutical agents.
  • Discussion of the role of radiation oncologists in RPT.

Main Results:

  • RPT leverages radiation oncology expertise in a new therapeutic context.
  • Understanding RPT indications and regulations is crucial for adoption.
  • RPT requires interdisciplinary collaboration.

Conclusions:

  • Radiopharmaceutical therapy (RPT) presents a significant opportunity for radiation oncologists.
  • Familiarity with RPT indications and regulations is essential for practice integration.
  • RPT facilitates a collaborative approach to cancer treatment, enhancing patient care.