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Updated: Sep 1, 2025

Microcrystal Electron Diffraction of Small Molecules
Published on: March 15, 2021
Electron Diffraction of 3D Molecular Crystals
Ambarneil Saha1,2, Shervin S Nia1,2, José A Rodríguez1,2
1UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, California 90095, United States.
Abstract:
Electron crystallography has a storied history which rivals that of its more established X-ray-enabled counterpart. Recent advances in data collection and analysis have sparked a renaissance in the field, opening a new chapter for this venerable technique. Burgeoning interest in electron crystallography has spawned innovative methods described by various interchangeable labels (3D ED, MicroED, cRED, etc.). This Review covers concepts and findings relevant to the practicing crystallographer, with an emphasis on experiments aimed at using electron diffraction to elucidate the atomic structure of three-dimensional molecular crystals.
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