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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
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Systemic inflammation after stroke: implications for post-stroke comorbidities.

Alba Simats1, Arthur Liesz1,2

  • 1Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

EMBO Molecular Medicine
|August 16, 2022
PubMed
Summary
This summary is machine-generated.

Stroke impacts both brain inflammation and the body's overall immune system. Understanding this systemic immune response is key to developing new stroke therapies and managing related health issues.

Keywords:
inflammationlong-term outcomepost-stroke comorbiditiesstrokesystemic immunity

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Area of Science:

  • Neuroscience
  • Immunology
  • Translational Medicine

Background:

  • Stroke research increasingly focuses on immunological mechanisms.
  • Modulating neuroinflammation is a promising therapeutic strategy for ischemic brain protection.
  • Stroke triggers both local neuroinflammatory responses and systemic immune alterations.

Purpose of the Study:

  • To review the effects of ischemic stroke on systemic immunity across all disease stages.
  • To discuss the mechanisms of systemic-brain immune communication.
  • To explore the role of systemic immunity in stroke comorbidities and potential therapeutic targets.

Main Methods:

  • Literature review of translational stroke research.
  • Analysis of immunological consequences of ischemic stroke.
  • Examination of systemic immune responses and brain-immune interactions.

Main Results:

  • Ischemic stroke significantly impacts systemic immunity from onset to long-term outcomes.
  • Systemic immune changes influence the brain's response to stroke.
  • Systemic immunity plays a role in common stroke comorbidities like cardiac dysfunction, atherosclerosis, diabetes, and infections.

Conclusions:

  • Targeting systemic immunity post-stroke offers a novel therapeutic avenue.
  • Interventions modulating systemic immunity may improve long-term stroke outcomes.
  • Addressing systemic immune dysregulation can help alleviate stroke-related comorbidities.