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Related Experiment Videos

Zone 2 and zone 3 pulmonary blood flow.

S L Soohoo, H S Goldberg, R Graham

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |May 1, 1987
    PubMed
    Summary

    Critical pressures (Pcrit) are the key backpressure in pulmonary blood flow, even in zone 3. This finding refines the West model by showing Pcrit, not alveolar pressure, dictates flow dynamics.

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    Area of Science:

    • Pulmonary Physiology
    • Cardiovascular Research
    • Hemodynamics

    Background:

    • The West model explains pulmonary blood flow distribution using zones based on pressure gradients.
    • Traditionally, alveolar pressure (PA) is considered the critical backpressure in zone 3.
    • Recent research suggests critical pressures (Pcrit) may influence flow initiation and maintenance.

    Purpose of the Study:

    • To test if critical pressures (Pcrit) act as the pertinent backpressure to pulmonary blood flow, even in zone 3.
    • To re-examine the explanation for increased flow in West zone 3 considering Pcrit.
    • To refine the zonal model of pulmonary circulation.

    Main Methods:

    • Used two methods in an isolated canine left caudal lobe model.
    • Maintained alveolar pressure (PA) at 5 cmH2O.
    • Obtained pressure-flow (P-Q) characteristics and varied pulmonary venous pressure (Ppv) at constant flow.

    Main Results:

    • The pertinent backpressure to flow was consistently the greater of Pcrit or Ppv.
    • Alveolar pressure (PA) was never the pertinent backpressure.
    • No significant changes in flow channel geometry were observed between zone 2 and zone 3.

    Conclusions:

    • Critical pressures (Pcrit) are the relevant backpressure in pulmonary circulation, challenging the traditional West model.
    • Pulmonary venous pressure (Ppv) also influences backpressure when exceeding PA but below Pcrit.
    • These findings necessitate a revision of the zonal model for pulmonary blood flow.

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