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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

397
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
397
Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

608
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
608
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

455
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
455
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

405
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
405
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

255
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
255
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

783
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
783

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Related Experiment Video

Updated: Sep 1, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

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Ionic Liquids-Based Drug Delivery: a Perspective.

Yi Lu1,2,3, Jianping Qi1,2, Wei Wu4,5,6,7

  • 1Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai, 201203, China.

Pharmaceutical Research
|August 16, 2022
PubMed
Summary
This summary is machine-generated.

Ionic liquids (ILs) offer novel solutions for drug delivery by liquidizing active pharmaceutical ingredients (APIs). This perspective reviews IL applications and emerging challenges in pharmaceutical development.

Keywords:
Drug deliveryIonic liquidsPerspective

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Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Ionic liquids (ILs) are explored for overcoming limitations of solid active pharmaceutical ingredients (APIs).
  • ILs offer potential as liquidizing agents, solubilizers, green solvents, and permeation enhancers.
  • Their unique properties present novel opportunities in drug formulation and delivery.

Purpose of the Study:

  • To provide an overview of current ionic liquid (IL) applications in drug delivery.
  • To highlight the potential of ILs in addressing unmet needs in biomedicines.
  • To identify and discuss emerging challenges associated with IL-based drug delivery systems.

Main Methods:

  • Literature review and perspective synthesis.
  • Analysis of existing research on ILs in pharmaceutical applications.
  • Identification of key challenges and future research directions.

Main Results:

  • Ionic liquids (ILs) demonstrate versatility in liquidizing or solubilizing APIs.
  • ILs show promise as green solvents and enhancers for drug permeation.
  • New challenges arise with the increasing use of ILs in drug delivery systems.

Conclusions:

  • Ionic liquids (ILs) represent a promising frontier in pharmaceutical technology for advanced drug delivery.
  • Further research is needed to address the challenges and optimize the use of ILs in biomedicines.
  • Understanding the complexities of IL-based systems is crucial for their successful clinical translation.