Related Experiment Video

Updated: Sep 1, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Hippo: A New Hub for Atherosclerotic Disease

Xi-Yan Liu1, Kun Zhou1, Kai-Jiang Tian1

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang 421001, China.

Current Pharmaceutical Design
|August 17, 2022
PubMed

Insights

The Hippo signaling pathway regulates cell growth and is linked to cardiovascular disease. This review explores Hippo

Area of Science:

  • Molecular Biology
  • Cardiovascular Biology
  • Cell Signaling

Background:

  • The Hippo signaling pathway is crucial for maintaining tissue homeostasis and organ development.
  • Dysregulation of Hippo signaling is implicated in various diseases, including cardiovascular conditions.
  • Atherosclerosis, a prevalent cardiovascular disease, involves chronic vascular inflammation and cellular dysfunction.

Purpose of the Study:

  • To elucidate the role of the Hippo signaling pathway in the pathophysiology of atherosclerosis.
  • To identify potential molecular targets of Hippo signaling in atherosclerosis.
  • To discuss the implications of Hippo signaling in cardiovascular disease and related pharmacology.

Main Methods:

  • Literature review focusing on Hippo signaling, atherosclerosis, and cardiovascular disease.
  • Analysis of existing research on molecular mechanisms and cellular processes involved.
  • Synthesis of information regarding Hippo pathway's role in endothelial cells, smooth muscle cells, and macrophages.

Main Results:

  • Hippo signaling acts as a central regulator in maintaining cellular balance and tissue development.
  • Evidence suggests a strong link between Hippo pathway dysregulation and the development of atherosclerosis.
  • Oxidized Low-Density Lipoprotein (LDL) and autophagy are identified as factors influencing atherosclerosis, potentially modulated by Hippo signaling.

Conclusions:

  • The Hippo signaling pathway is a key hub in regulating atherosclerosis.
  • Understanding Hippo's regulatory mechanisms offers potential therapeutic targets for cardiovascular diseases.
  • Further research into Hippo signaling's role in atherosclerosis pathophysiology and pharmacology is warranted.

Keywords:
Hippoautophagyendothelial celllipid metabolismmacrophagessmooth muscle cells

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