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Updated: Sep 1, 2025
10:17
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
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[CME: Can Slim People Have Type-2 Diabetes?]
Simona Danioth1, Peter Wiesli1
1Medizinische Klinik, Endokrinologie und Diabetologie, Kantonsspital Frauenfeld, Schweiz.
Praxis
|August 17, 2022
Summary
Slim individuals diagnosed with type 2 diabetes mellitus may have other underlying conditions. Alternative diagnoses like type 1 diabetes, genetic diabetes (MODY, mitochondrial), or pancreatic exocrine disease should be considered in non-obese patients.
Area of Science:
- Endocrinology and Metabolism
- Diabetology
Background:
- Type 2 diabetes mellitus (T2DM) is strongly associated with obesity and overweight individuals.
- Atypical presentations of T2DM in lean individuals warrant careful differential diagnosis.
Purpose of the Study:
- To explore the differential diagnoses for type 2 diabetes mellitus in patients who are not overweight or obese.
- To highlight the importance of considering alternative diabetes types in slim individuals.
Main Methods:
- Review of clinical guidelines and literature concerning diabetes diagnosis in non-obese populations.
- Analysis of case studies presenting with T2DM symptoms but without excess weight.
Main Results:
- In lean patients suspected of having T2DM, other forms of diabetes are frequently overlooked.
- Conditions such as adult-onset type 1 diabetes, genetic forms (MODY, mitochondrial diabetes), and pancreatic exocrine disease are potential alternative diagnoses.
Conclusions:
- The diagnosis of type 2 diabetes mellitus in slim individuals requires consideration of alternative etiologies.
- Diseases of the exocrine pancreas are a commonly underdiagnosed cause of diabetes in lean patients.
- Broadening the diagnostic scope is crucial for accurate patient management.
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