Related Experiment Video

Updated: Sep 1, 2025

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

765

Biochemical Factors Affecting Thrombosis Development in Permanent Tunneled Hemodialysis Catheter

Helin El-Kilic, Nilufer Bektas, Ahmet I Balkaya

    Clinical Laboratory
    |August 17, 2022
    PubMed

    Insights

    Higher BMI, infection, D-dimer, and procalcitonin levels are key factors increasing thrombosis risk after tunneled dialysis catheter (TDC) placement. These findings are crucial for preventing blood clots in dialysis patients.

    Area of Science:

    • Nephrology
    • Vascular Surgery
    • Hematology

    Background:

    • Thrombosis is a significant complication following tunneled dialysis catheter (TDC) insertion.
    • Identifying biochemical factors predicting TDC thrombosis is critical for patient management.

    Purpose of the Study:

    • To investigate biochemical and clinical predictors of thrombosis in patients with permanent TDC.
    • To determine the association between specific biomarkers and thrombosis development.

    Main Methods:

    • Retrospective analysis of 350 patients undergoing permanent TDC placement (2013-2020).
    • Comparison of demographic data, blood test results, and complications between patients with and without thrombosis.
    • Logistic regression analysis to identify independent risk factors for thrombosis.

    Main Results:

    • Elevated Body Mass Index (BMI) > 30 kg/m², diabetes mellitus, and infective complications were more common in patients with thrombosis.
    • Significantly higher D-dimer and procalcitonin levels were observed in the thrombosis group.
    • Logistic regression identified BMI > 30 kg/m² (OR 3.842) and infective complications (OR 3.104) as independent risk factors for thrombosis.

    Conclusions:

    • Infection, BMI > 30 kg/m², D-dimer > 3 µg/mL, and procalcitonin > 2 ng/mL are significant predictors of thrombosis after TDC insertion.
    • These factors can aid in risk stratification and prevention strategies for TDC-related thrombosis.
    Abstract

    More Related Videos

    In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time09:19

    In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

    Published on: May 24, 2020

    9.1K
    Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow09:41

    Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

    Published on: March 5, 2020

    9.4K

    Related Concept Videos

    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    867
    Hemodialysis I: Introduction01:25

    Hemodialysis I: Introduction

    Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
    266
    Venous Thrombosis III: Interprofessional Care01:29

    Venous Thrombosis III: Interprofessional Care

    Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
    18
    Hemodialysis II: Procedure and Complications01:24

    Hemodialysis II: Procedure and Complications

    DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
    124
    Venous Thrombosis I: Introduction01:30

    Venous Thrombosis I: Introduction

    Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
    37
    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    1.2K