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Updated: Sep 1, 2025

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Tandem synthesis of N-methylated tertiary amines via three-component coupling of carbonyl compounds, amines, and
Ishani Borthakur1, Sameer Srivastava1, Saloni Kumari1
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India. sabuj@iitk.ac.in.
Abstract:
An Ir-catalyzed tandem synthesis of various N-methylated tertiary amines from three-component coupling of carbonyl compounds, amines, and methanol following reductive amination/N-methylation is reported for the first time. A wide array of substrates with tolerance of different functional groups was demonstrated. The protocol was extended to the synthesis of N-methyl containing pharmaceutically important drug molecules. A probable catalytic cycle was proposed based on various control experiments and different analytical techniques such as NMR, IR and ESI-MS.
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