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Iridoids as a Potential Hepatoprotective Class: A Review

Raquel Bridi1, Gilsane Lino von Poser2, Gabriela de Carvalho Meirelles2

  • 1Departamento de Química Farmacológica y Toxicológica, Facultad de Ciências Químicas y Farmacéuticas, Universidad de Chile, Santiago, 8380000, Chile.

Mini Reviews in Medicinal Chemistry
|August 17, 2022
PubMed
Abstract

Insights

Iridoids, natural compounds from medicinal plants, show significant potential for treating liver disease due to their proven hepatoprotective effects. This review highlights 63 such compounds, offering hope for safer liver disease therapies.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Hepatology

Background:

  • Liver disease prevalence is rising globally, driven by lifestyle factors and infections.
  • Current hepatoprotective drugs have limitations, increasing interest in plant-derived remedies.
  • Iridoids from medicinal plants are recognized for their bitter taste and potential liver-protective properties.

Approach:

  • Comprehensive literature search conducted across major scientific databases until December 2021.
  • Focused on studies investigating the hepatoprotective activity of iridoids and iridoid-rich extracts.
  • Systematic review of in vitro and in vivo evidence for iridoid efficacy.

Key Points:

  • Identified 63 distinct hepatoprotective iridoids.
  • Aucubin, catalpol, and picroliv are among the most studied iridoids.
  • Demonstrated protective actions against various hepatotoxic agents.

Conclusions:

  • Iridoids represent a promising class of natural compounds for liver disease treatment.
  • Further research into their mechanisms of action is warranted.
  • Potential for developing novel, safer therapeutic strategies for hepatic disorders.
Keywords:
Antioxidantsanti-inflammatoryhepatotoxicityiridoidsmechanismsoxidative stress

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