Related Experiment Video
Updated: Sep 1, 2025

Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
Iridoids as a Potential Hepatoprotective Class: A Review
Raquel Bridi1, Gilsane Lino von Poser2, Gabriela de Carvalho Meirelles2
1Departamento de Química Farmacológica y Toxicológica, Facultad de Ciências Químicas y Farmacéuticas, Universidad de Chile, Santiago, 8380000, Chile.
Iridoids, natural compounds from medicinal plants, show significant potential for treating liver disease due to their proven hepatoprotective effects. This review highlights 63 such compounds, offering hope for safer liver disease therapies.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Hepatology
Background:
- Liver disease prevalence is rising globally, driven by lifestyle factors and infections.
- Current hepatoprotective drugs have limitations, increasing interest in plant-derived remedies.
- Iridoids from medicinal plants are recognized for their bitter taste and potential liver-protective properties.
Approach:
- Comprehensive literature search conducted across major scientific databases until December 2021.
- Focused on studies investigating the hepatoprotective activity of iridoids and iridoid-rich extracts.
- Systematic review of in vitro and in vivo evidence for iridoid efficacy.
Key Points:
- Identified 63 distinct hepatoprotective iridoids.
- Aucubin, catalpol, and picroliv are among the most studied iridoids.
- Demonstrated protective actions against various hepatotoxic agents.
Conclusions:
- Iridoids represent a promising class of natural compounds for liver disease treatment.
- Further research into their mechanisms of action is warranted.
- Potential for developing novel, safer therapeutic strategies for hepatic disorders.
More Related Videos
07:40Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Related Concept Videos
Hepatic Drug Excretion: Influencing Factors
Cancer Prevention
Some...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Hepatic Drug Clearance: Role of Transporters
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents