Role of Systemic Immune-Inflammatory Index in Predicting the Development of In-Hospital Malignant Ventricular
Emrah Aksakal1, Uğur Aksu2, Oğuzhan Birdal3
1Department of Cardiology, Erzurum Region Training and Research Hospital, Erzurum, Turkey.
Insights
The systemic immune-inflammatory index (SII) can predict malignant ventricular arrhythmias (MVA) in ST-elevation myocardial infarction (STEMI) patients. This inflammatory marker shows greater predictive power than other inflammatory markers for MVA development post-STEMI.
Area of Science:
- Cardiology
- Immunology
- Biomarkers
Background:
- ST-elevation myocardial infarction (STEMI) is linked to numerous complications.
- The systemic immune-inflammatory index (SII) reflects inflammation and may correlate with cardiovascular disease.
- Malignant ventricular arrhythmias (MVA) are a serious complication following STEMI.
Purpose of the Study:
- To investigate the association between SII and the development of MVA in STEMI patients.
- To identify independent predictors of MVA in the STEMI population.
Main Methods:
- A cohort of 1708 STEMI patients was analyzed.
- Propensity score matching (PSM) was employed to create comparable groups.
- Univariate and regression analyses identified predictors of MVA.
Main Results:
- After PSM, 158 patients (61.6 years mean age, 68.4% male) were analyzed.
- Neutrophil count, SII, CRP, albumin, and CAR were associated with MVA in univariate analysis.
- SII and CRP/albumin ratio (CAR) emerged as independent predictors of MVA.
Conclusions:
- The systemic immune-inflammatory index (SII) is a significant independent predictor of MVA development in STEMI patients.
- SII demonstrates superior predictive value for MVA compared to other inflammatory markers.
- SII holds potential for clinical application in risk stratification for STEMI patients.
Abstract:
Many complications can be observed after ST-elevation myocardial infarction (STEMI). The systemic immune-inflammatory index (SII) is a sensitive indicator of the inflammatory state, and this parameter may also be associated with cardiovascular diseases. In this study, we investigated the relationship between malignant ventricular arrhythmias (MVA) development and SII in STEMI patients. A total of 1708 STEMI patients were included in the study. Propensity score matching (PSM) analysis was performed. Patients were divided into 2 groups according to the development of MVA, and predictors of MVA development were investigated. After the PSM analysis, the mean age of 158 patients was 61.6 years, and 68.4% were male. In the univariate analysis, neutrophil count, SII, C-reactive protein (CRP), albumin, and CRP/albumin ratio (CAR) were associated with the development of MVA; while in the regression analysis, CAR and SII was found to be independent predictors of the development of MVA. In this study, we demonstrated that SII is a better independent predictor than other inflammatory parameters for predicting the development of MVA. This index may be useful in clinical use.
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