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Brain functional connectivity differences between responders and non-responders to sleeve gastrectomy
Carlo A Mallio1, Giuseppe Spagnolo2, Claudia Piervincenzi3
1Unit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. c.mallio@policlinicocampus.it.
Neuroradiology
|August 17, 2022
Summary
Brain connectivity differs between individuals who respond well or poorly to sleeve gastrectomy (SG). These findings offer insights into the neural mechanisms underlying surgical outcomes in obesity treatment.
Area of Science:
- Neuroscience
- Medical Imaging
- Bariatric Surgery
Background:
- Obesity is a complex metabolic disorder associated with altered brain function.
- Sleeve gastrectomy (SG) is an effective bariatric surgery for weight loss.
- Understanding the neural correlates of SG response is crucial for personalized treatment.
Purpose of the Study:
- To compare resting-state functional connectivity (RSFC) in obese patients who responded to SG versus non-responders.
- To compare these groups with obese individuals without prior bariatric surgery.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was used.
- Data were acquired using a 1.5 Tesla MRI scanner.
- Statistical analysis employed a significance threshold of p < 0.05, family-wise error (FWE) corrected.
Main Results:
- Responders exhibited lower within-network RSFC in default mode and frontoparietal networks compared to controls and non-responders.
- Non-responders showed higher RSFC in the lateral visual network compared to controls.
- Responders displayed higher anti-correlation between executive control and salience networks, correlating positively with excess weight loss.
Conclusions:
- Significant differences in brain functional connectivity exist between SG responders and non-responders.
- These findings provide novel insights into the neural basis of surgical outcomes in SG patients.
- The study expands knowledge on neural mechanisms potentially influencing response to bariatric surgery.
