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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Non-LTR Retrotransposons

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Mechanisms of Retrovirus-induced Cancers

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Rous Sarcoma Virus (RSV) and Cancer

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Related Experiment Video

Updated: Sep 1, 2025

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

Long noncoding RNAs in hepatitis B virus replication and oncogenesis.

Hui-Chun Li¹, Chee-Hing Yang², Shih-Yen Lo²

¹Department of Biochemistry, Tzu Chi University, Hualien 97004, Taiwan.

World Journal of Gastroenterology

|August 18, 2022

Summary

Long noncoding RNAs (lncRNAs) play roles in hepatitis B virus (HBV) replication and liver cancer (HCC). Dysregulated lncRNAs in HBV-related HCC may offer new diagnostic markers and therapeutic targets.

Keywords:

Biomarker Hepatitis B virus Hepatitis B virus X protein Hepatocellular carcinoma Long noncoding RNAs

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Last Updated: Sep 1, 2025

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

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Published on: February 1, 2017

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

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Published on: June 5, 2020

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Area of Science:

Molecular Biology
Hepatology
Oncology

Background:

Hepatocellular carcinoma (HCC) associated with Hepatitis B virus (HBV) infection has a poor prognosis.
Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in HBV replication and oncogenesis.
The HBV X protein significantly influences the dysregulation of many lncRNAs in HBV-related HCC.

Purpose of the Study:

To summarize recent findings on the role of lncRNAs in HBV replication and HBV-related HCC.
To highlight the potential of dysregulated lncRNAs as biomarkers for early diagnosis and therapeutic targets in HCC.

Main Methods:

This mini-review synthesizes existing literature on lncRNAs in HBV infection and HCC.
Focuses on recent developments in understanding lncRNA regulation, genetic polymorphisms, and clinical implications.

Main Results:

Diverse lncRNAs are involved in HBV replication and oncogenesis, particularly in HBV-related HCC.
Mechanisms of lncRNA regulation and the impact of genetic polymorphisms are being elucidated.
Dysregulated lncRNAs show promise as potential biomarkers and therapeutic targets for HCC.

Conclusions:

lncRNAs are critical players in the pathogenesis of HBV-related HCC.
Further research into lncRNAs could lead to improved diagnostic tools and novel treatment strategies for HCC.