Rebuilding trust in proton pump inhibitor therapy
Alla Turshudzhyan1, Sonia Samuel2, Angela Tawfik3
1Department of Medicine, University of Connecticut, Farmington, CT 06030, United States.
World Journal of Gastroenterology
|August 18, 2022
Summary
Proton pump inhibitor (PPI) therapy is widely used for acid-related diseases but often overprescribed. This review clarifies PPI guidelines, indications, and side-effect evidence to ensure informed patient-physician decisions.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) have transformed acid-related disease treatment.
- Widespread PPI use has led to concerns regarding overprescription and potential side effects.
Purpose of the Study:
- To increase awareness of current proton pump inhibitor (PPI) guidelines.
- To discuss evidence-based clinical indications for PPI therapy.
- To clarify reported PPI side effects and address patient/provider concerns.
Main Methods:
- Review of current clinical guidelines on PPI use.
- Analysis of evidence supporting PPI indications.
- Examination of studies detailing PPI side-effect profiles.
Main Results:
- PPIs are frequently overprescribed in primary care and emergency settings.
- Physicians often initiate PPI therapy due to a perceived low side-effect profile.
- Growing concerns exist among patients and providers regarding PPI side effects.
Conclusions:
- Informed, evidence-based decisions regarding PPI initiation/continuation are crucial.
- Clarifying the evidence behind PPI side effects can alleviate current concerns.
- Promoting proper PPI use optimizes patient care and minimizes unnecessary therapy.
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