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The BioFire® RP2.1 Panel Did Not Identify Concurrent Respiratory Virus Infection in Adults with Variable SARS-CoV-2
Kendra M Quicke1, Bridget A Baxter2, Sophia Stromberg2
1Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins 80526, CO, USA.
Advances in Virology
|August 18, 2022
Summary
Coinfections with other respiratory viruses were uncommon in COVID-19 patients in Colorado. Public health measures likely reduced the rates of these concurrent infections, which did not explain COVID-19 severity variations.
Area of Science:
- Virology
- Epidemiology
- Infectious Diseases
Background:
- The emergence of SARS-CoV-2 caused a global pandemic.
- The impact of coinfections on COVID-19 severity and duration remains unclear.
Purpose of the Study:
- To investigate the prevalence of coinfections with other respiratory pathogens in SARS-CoV-2 positive individuals.
- To determine if coinfections correlate with increased COVID-19 severity or prolonged infection duration.
Main Methods:
- Retrospective analysis of nasopharyngeal swabs from SARS-CoV-2 PCR-positive individuals in Colorado (March 2020 - May 2021).
- Testing for 21 additional respiratory pathogens (17 viral, 4 bacterial).
- Correlation analysis between SARS-CoV-2 RNA levels, infectious virus titers, disease severity, and coinfection status.
Main Results:
- Significant positive correlations were found between SARS-CoV-2 RNA levels and infectious virus titers.
- A positive correlation existed between viral RNA levels and disease severity in one cohort.
- Only one case of coinfection (SARS-CoV-2 and human rhinovirus/enterovirus) was detected.
- Concurrent viral respiratory coinfections were rare during the study period.
Conclusions:
- Viral respiratory coinfections were uncommon in the studied COVID-19 population.
- Coinfections were unlikely to be the cause of observed variations in COVID-19 severity and infection duration.
- Public health measures, such as mask-wearing, likely contributed to the low coinfection rates.
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