Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Discrete-Time Fourier Series01:20

Discrete-Time Fourier Series

343
The Discrete-Time Fourier Series (DTFS) is a fundamental concept in signal processing, serving as the discrete-time counterpart to the continuous-time Fourier series. It allows for the representation and analysis of discrete-time periodic signals in terms of their frequency components. Unlike its continuous counterpart, which utilizes integrals, the calculation of DTFS expansion coefficients involves summations due to the discrete nature of the signal.
For a discrete-time periodic signal x[n]...
343
Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

1.1K
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
1.1K
Atomic Fluorescence Spectroscopy01:29

Atomic Fluorescence Spectroscopy

480
Atomic fluorescence spectroscopy (AFS) is an analytical technique that involves the electronic transitions of atoms in a flame, furnace, or plasma being excited by electromagnetic (EM) radiation. When these atoms absorb energy, they become excited and subsequently release energy as they return to their original state. This emitted light, or "fluorescence," is observed at a right angle to the incident beam. Both absorption and emission processes transpire at distinct wavelengths, which...
480
UV–Vis Spectroscopy: Woodward–Fieser Rules01:29

UV–Vis Spectroscopy: Woodward–Fieser Rules

25.2K
UV–Visible absorption spectra of conjugated dienes arise from the lowest energy π → π* transitions. The light-absorbing part of the molecule is called the chromophore, and the substituents directly attached to the chromophore are called auxochromes. A strong correlation exists between the absorption maxima, λmax, and the structure of a conjugated π system. The Woodward–Fieser rules predict the value of λmax for a given...
25.2K
IR Spectroscopy: Molecular Vibration Overview01:24

IR Spectroscopy: Molecular Vibration Overview

2.7K
When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
2.7K
IR Spectrometers01:25

IR Spectrometers

1.4K
There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MW-FlexNIRS: wearable, low-cost, LED-based, multi-wavelength NIRS oximeter for cytochrome c oxidase recovery in neonates.

Biomedical optics express·2026
Same author

Locoregional lactate dehydrogenase inhibition potentiates therapy and overcomes treatment resistance in hepatocellular carcinoma.

Hepatology (Baltimore, Md.)·2026
Same author

Comparative validation of speckle contrast optical spectroscopy against diffuse correlation spectroscopy for monitoring human cerebral blood flow.

Neurophotonics·2026
Same author

On-body measure of reaction time correlates with intoxication level.

PloS one·2026
Same author

The LIFT UP study: feasibility of systematically identifying and addressing resource needs in those with metastatic breast cancer.

Breast cancer research and treatment·2026
Same author

The landscape of the intestinal microbiome among patients with newly diagnosed invasive breast cancer and ductal carcinoma in situ (DCIS).

NPJ breast cancer·2026
Same journal

CEST MRI reveals nicotine-induced alterations in glutamate-associated molecular connectivity in the mouse brain.

Frontiers in neuroscience·2026
Same journal

Brain protein burden is related to intravoxel incoherent motion: PET-MR imaging study.

Frontiers in neuroscience·2026
Same journal

Screening the optimal rTSMS frequency to orchestrate immune-fibrotic remodeling for adult spinal cord repair.

Frontiers in neuroscience·2026
Same journal

Assessment of tenecteplase target-associated pathogenic mechanisms underlying depression in acute ischemic stroke patients: insights from artificial intelligence-driven multi-omics analysis and <i>in vitro</i> validation.

Frontiers in neuroscience·2026
Same journal

Sex-divergent intrinsic brain function in Parkinson's disease: elevated nigral fluctuations and premotor-visuospatial coupling in female patients.

Frontiers in neuroscience·2026
Same journal

Spatial transcriptomics on an expanded dataset at the brain-electrode interface: exploration of variability and identification of novel biomarkers.

Frontiers in neuroscience·2026
See all related articles

Related Experiment Video

Updated: Sep 1, 2025

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells
14:12

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells

Published on: December 11, 2021

5.5K

Functional Time Domain Diffuse Correlation Spectroscopy.

Nisan Ozana1, Niyom Lue2, Marco Renna1

  • 1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Frontiers in Neuroscience
|August 18, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces an advanced time-domain diffuse correlation spectroscopy (TD-DCS) system for enhanced brain imaging. The new system achieves high-resolution cerebral blood flow (CBF) measurements, enabling real-time monitoring of brain activity.

Keywords:
cerebral blood flowdiffuse correlation spectroscopy (DCS)fNIRS (functional near infrared spectroscopy)neuroimaging (anatomic and functional)optical neuroimaging

More Related Videos

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.1K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

11.5K

Related Experiment Videos

Last Updated: Sep 1, 2025

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells
14:12

Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells

Published on: December 11, 2021

5.5K
Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy
12:06

Molecular Diffusion in Plasma Membranes of Primary Lymphocytes Measured by Fluorescence Correlation Spectroscopy

Published on: February 1, 2017

11.1K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

11.5K

Area of Science:

  • Biomedical Optics
  • Neuroimaging
  • Physiological Monitoring

Background:

  • Time-domain diffuse correlation spectroscopy (TD-DCS) is a promising technique for functional brain imaging by quantifying cerebral blood flow (CBF).
  • Previous TD-DCS systems faced limitations in signal-to-noise ratio (SNR), hindering the temporal resolution required for dynamic functional measurements.

Purpose of the Study:

  • To develop and validate a next-generation optimized TD-DCS system with improved SNR and temporal resolution.
  • To demonstrate the system's capability for high-fidelity CBF measurements during functional tasks.

Main Methods:

  • Utilized a custom 1,064 nm amplified laser source, high-resolution time-tagging, and superconducting nanowire single-photon detectors (SNSPDs).
  • System characterization performed using intralipid phantoms.
  • Functional CBF measurements conducted in six human subjects during breath-holding and cognitive tasks.

Main Results:

  • Achieved high temporal resolution (over 5 Hz) for CBF signal acquisition.
  • Successfully measured blood flow responses to functional tasks and breath-holding using TD-DCS.
  • Demonstrated the feasibility of high-spatial resolution functional brain imaging with the optimized system.

Conclusions:

  • The optimized TD-DCS system significantly enhances the capability for non-invasive functional brain imaging.
  • This advancement allows for the direct quantification of CBF changes with unprecedented temporal resolution.
  • The system opens new avenues for studying neurovascular coupling and brain function in real-time.