Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structures of membrane proteins.

S J Kennedy

    The Journal of Membrane Biology
    |September 19, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Integral membrane proteins adopt specific structures like alpha helices or beta helices to function within lipid bilayers. Beta helices offer unique advantages for transmembrane ion channel models.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tuneable Magnetic Phase Transitions in Layered CeMn2Ge(2-x)Six Compounds.

    Scientific reports·2015
    Same author

    Magnetism and magnetic structures of PrMn2Ge2-xSix.

    Journal of physics. Condensed matter : an Institute of Physics journal·2013
    Same author

    Driving magnetostructural transitions in layered intermetallic compounds.

    Physical review letters·2013
    Same author

    The magnetocaloric effect and critical behaviour of the Mn(0.94)Ti(0.06)CoGe alloy.

    Journal of physics. Condensed matter : an Institute of Physics journal·2012
    Same author

    Critical magnetic transition in TbNi2Mn--magnetization and Mössbauer spectroscopy.

    Journal of physics. Condensed matter : an Institute of Physics journal·2011
    Same author

    Doubly curved crystal point-focusing x-ray monochromators: geometrical and practical optics.

    Applied optics·2010

    Area of Science:

    • Biochemistry
    • Structural Biology
    • Membrane Biophysics

    Background:

    • Integral membrane proteins function within the hydrophobic lipid bilayer.
    • Protein structure is influenced by its surrounding environment.
    • Regular secondary structures are essential for membrane protein stability.

    Purpose of the Study:

    • To explore possible conformations of integral membrane proteins.
    • To propose beta helices as a suitable structure for transmembrane proteins.
    • To model the activation of transmembrane protein channels.

    Main Methods:

    • Discussion of alpha helices, beta-pleated sheets, and beta helices as models.
    • Analysis of the glycophorin protein structure.
    • Development of a model for transmembrane protein activation.

    Related Experiment Videos

    Main Results:

    • Beta helices possess features suitable for the lipid bilayer.
    • A beta helix model for glycophorin shows a hydrophobic exterior and polar interior.
    • The proposed model accurately reproduces nerve channel kinetics and voltage dependence.

    Conclusions:

    • Beta helices are a viable and potentially advantageous conformation for integral membrane proteins.
    • The beta helix structure could facilitate transmembrane ion channel function.
    • A dynamic equilibrium model between alpha and beta helices explains channel activation.