Calibration methods for flow rates down to 5 nL/min and validation methodology.
Chris Mills1, Elsa Batista2, Hugo Bissig3
1TÜV SÜD National Engineering Laboratory, Glasgow, Scotland.
Biomedizinische Technik. Biomedical Engineering
|August 18, 2022
Summary
Accurate micro-flow and nano-flow measurements are crucial for drug delivery devices. This study introduces new traceable calibration methods and presents inter-laboratory results for flow meters and syringe pumps.
Area of Science:
- Metrology
- Biomedical Engineering
- Fluid Dynamics
Background:
- Accurate measurement of volume, flow, and pressure is vital for drug delivery devices, especially at low flow rates.
- Existing metrological infrastructure requires expansion for micro-flow and nano-flow measurements.
Purpose of the Study:
- To investigate new traceable techniques for micro-flow and nano-flow rate measurements.
- To expand metrological capabilities for low flow rate applications in medical devices.
Main Methods:
- Development of new calibration methods for micro-flow and nano-flow rates.
- Inter-laboratory comparison involving nine laboratories.
- Calibration of two distinct flow meters and a syringe pump.
Main Results:
- Demonstration of traceable techniques for flow rate measurement from 5 nL/min to 1,500 nL/min.
- Presentation of inter-comparison results for flow meter and syringe pump calibration.
- Validation of new methods through multi-laboratory participation.
Conclusions:
- New traceable calibration methods are essential for accurate low flow rate measurements.
- Expanded metrological infrastructure is needed to support advanced drug delivery systems.
- Inter-laboratory comparisons confirm the reliability of the developed techniques.
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