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Effect of SARS-CoV-2 infection on asthma patients

Xin-Yu Li1,2, Jing-Bing Wang1, Hong-Bang An3

  • 1Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Frontiers in Medicine
|August 19, 2022
PubMed

Insights

This study used bioinformatics to find shared molecular pathways between asthma and COVID-19. It identified potential drug targets, offering insights into treating both conditions.

Area of Science:

  • Genomics
  • Bioinformatics
  • Respiratory Medicine

Background:

  • Asthma is a prevalent chronic inflammatory airway disease.
  • Coronavirus disease 2019 (COVID-19) is a severe respiratory illness caused by SARS-CoV-2.
  • The molecular relationship between asthma and COVID-19 is not well understood.

Purpose of the Study:

  • To investigate shared molecular pathways and signatures between asthma and COVID-19.
  • To identify potential therapeutic drug candidates for both conditions.
  • To explore the link between SARS-CoV-2 infection and asthma patients.

Main Methods:

  • Transcriptome analysis of RNA-seq data from asthma and COVID-19 patients (GSE147507, GSE74986).
  • Identification of differentially expressed genes (DEGs) common to both diseases.
  • Construction of a protein-protein interaction (PPI) network to find hub genes.

Main Results:

  • 66 common differentially expressed genes were identified between asthma and COVID-19.
  • Five key hub genes were discovered through PPI network analysis.
  • Shared molecular links between asthma and COVID-19 progression were established, along with potential protein-drug interactions.

Conclusions:

  • Bioinformatics analysis revealed shared molecular mechanisms between COVID-19 and asthma.
  • The identified common DEGs and hub genes may serve as therapeutic targets.
  • Further population studies are required to fully elucidate the molecular associations.
Abstract

Keywords:
COVID-19SARS-CoV-2asthmadifferentially expressed genesdrug moleculeshub genes

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