Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GhIMP10D, an inositol monophosphatase gene enhancing alkaline stress tolerance in plants.

Journal of advanced research·2026
Same author

Advances in Microenvironment-Responsive Biomaterials for Spinal Cord Injury Repair.

Advanced healthcare materials·2026
Same author

Anti-inflammatory activity of quinoa-based protein beverage after INFOGEST digestion: Peptide identification and molecular docking-based screening.

Food chemistry·2026
Same author

Genome-Wide identification and expression analysis revealed the potential role of CHS gene family responding to atmospheric pressure stress in Saussurea involucrata.

BMC plant biology·2025
Same author

Analogies of the Spatial Proximity of Polymer Racemate Glass and Crystal as Revealed by NMR Crystallography: "Freezing in" Crystallization.

ACS macro letters·2025
Same author

M2 polarization of macrophages: Manipulation of spinal cord injury repair.

Neural regeneration research·2025
Same journal

A review on assessment of advances in polymers and their hybrid nanosystem for leukaemia theranostics applications.

Biomedical materials (Bristol, England)·2026
Same journal

Controllable preparation of magnesium-hybridized PLA-PEG-PLA porous microspheres with anti-inflammatory function.

Biomedical materials (Bristol, England)·2026
Same journal

Core-shell fibrous threads loaded with VEGF plasmid polyplexes for sustained, threshold-guided gene delivery.

Biomedical materials (Bristol, England)·2026
Same journal

3-Layer lung cancer invasion model for evaluating MMP-targeted anti-metastatic therapeutics.

Biomedical materials (Bristol, England)·2026
Same journal

Enhancement of type H vessels in bone repair of rat tibial defects treated with stromal vascular fraction-collagen sponge composites.

Biomedical materials (Bristol, England)·2026
Same journal

Emulsion-based synthesis of polycaprolactone/bioactive glass 45S5 microparticles for bone regeneration applications.

Biomedical materials (Bristol, England)·2026
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K

Biomaterials with stiffness gradient for interface tissue engineering.

Jialun Cai1, Junjuan Wang2, Chenxuan Sun1

  • 1Department of Biomedical Engineering, College of Biology, Hunan University, Changsha 410082, People's Republic of China.

Biomedical Materials (Bristol, England)
|August 19, 2022
PubMed
Summary
This summary is machine-generated.

Interface tissue engineering uses stiffness-gradient biomaterials to improve tissue integration. These advanced scaffolds guide cell behavior for better tissue regeneration and development.

Keywords:
biomaterialsinterface tissuestiffness gradienttissue engineering

More Related Videos

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

20.0K

Related Experiment Videos

Last Updated: Aug 31, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.8K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

3.5K
Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

20.0K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Interface tissue engineering seeks to create engineered tissues that integrate seamlessly with multiple native tissue types.
  • Developing these interface tissues presents significant challenges, necessitating biomaterials with precise control over composition, stiffness, cell types, and biochemical cues.
  • Stiffness-controllable substrates, particularly those with a gradient of stiffness, are crucial for investigating cellular responses and enabling multi-lineage cell differentiation.

Purpose of the Study:

  • To review manufacturing techniques for fabricating scaffolds with a stiffness gradient.
  • To discuss characterization methods for these gradient scaffolds.
  • To explore the application of gradient biomaterials in regulating cellular behaviors and promoting interface tissue regeneration.

Main Methods:

  • Review of fabrication techniques for stiffness-gradient scaffolds.
  • Discussion of characterization methodologies for gradient biomaterials.
  • Analysis of how gradient stiffness influences cell attachment, migration, proliferation, and differentiation.

Main Results:

  • Stiffness-gradient biomaterials offer a tunable platform for controlling cell behavior.
  • Various manufacturing techniques enable the creation of scaffolds with controlled stiffness gradients.
  • These materials show promise for enhancing interface tissue organization and regeneration.

Conclusions:

  • Stiffness-gradient biomaterials are key to advancing interface tissue engineering.
  • Further research into fabrication, characterization, and application will drive progress in the field.
  • Addressing current challenges is essential for realizing the full potential of interface tissue regeneration.