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Related Experiment Video

Updated: Aug 31, 2025

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Neuroblast migration along cellular substrates in the developing porcine brain.

Demisha D L Porter¹, Sara N Henry², Sadia Ahmed²

¹Virginia Tech Graduate Program in Translational Biology, Medicine and Health, Virginia Polytechnic Institute and State University, Roanoke, VA, USA; Department of Biological Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Stem Cell Reports

|August 19, 2022

Summary

Newborn neurons (neuroblasts) in the developing brain use blood vessels as highways to reach their destinations. This study explores this pathway in piglets, offering insights into human brain development.

Keywords:

gliophilic migration neuroblast neurodevelopment neurogenesis porcine postnatal development subventricular zone swine vasophilic

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Published on: December 11, 2010

Related Experiment Videos

Last Updated: Aug 31, 2025

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain

Published on: December 11, 2010

Area of Science:

Developmental neuroscience
Neurobiology
Human brain development

Background:

Neuroblasts migrate long distances in the human brain postnatally to form cortical interneurons.
Understanding this migration is challenging due to limitations in studying human samples and differences in mouse models.
The role of cellular substrates in guiding neuroblast migration remains poorly understood.

Purpose of the Study:

To investigate the association between interneuronal migratory streams and their cellular substrates.
To explore potential guidance mechanisms for neuroblast migration in a gyrencephalic brain model.

Main Methods:

Evaluation of young interneuronal migratory streams in gyrencephalic piglets.
Analysis of preferred cellular substrates utilized by these migratory streams.
Study conducted during developmental stages equivalent to human birth, infancy, and toddlerhood.

Main Results:

Identified migratory streams of young interneurons in the developing piglet brain.
Observed an association between these migratory streams and specific cellular substrates.
Provided evidence for the utilization of cellular substrates in guiding neuroblast migration.

Conclusions:

Cellular substrates, potentially including blood vessels, may serve as crucial guidance cues for long-distance neuroblast migration.
Gyrencephalic piglets offer a relevant model for studying human-like cortical development and interneuron migration.
Further research is warranted to elucidate the precise molecular mechanisms governing substrate-guided neuroblast migration.