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Related Experiment Videos

Chronic intrathecal morphine for intractable pain.

R D Penn, J A Paice

    Journal of Neurosurgery
    |August 1, 1987
    PubMed
    Summary

    Intrathecal morphine via implanted pumps effectively manages intractable cancer pain, with 80% experiencing significant relief. This treatment also shows promise for carefully selected nonmalignant pain patients.

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    Area of Science:

    • Neurology
    • Pain Management
    • Oncology

    Background:

    • Intractable pain, including cancer-related and chronic nonmalignant pain, poses significant challenges.
    • Existing pain management strategies may be insufficient for severe cases.
    • Intrathecal drug delivery offers a targeted approach to pain relief.

    Purpose of the Study:

    • To evaluate the efficacy and safety of chronic intrathecal morphine for intractable pain.
    • To assess outcomes in patients with both cancer-related and nonmalignant pain.
    • To determine the suitability of implanted morphine delivery systems for long-term pain management.

    Main Methods:

    • A cohort of 43 patients with intractable pain received intrathecal morphine.
    • Pain was managed using continuous-infusion (Infusaid) or programmable (Medtronic) implanted devices.
    • Patients included those with cancer pain (35) and chronic nonmalignant pain (8).

    Main Results:

    • Excellent or good pain relief was achieved in 80% (28/35) of patients with cancer-related pain.
    • Side effects associated with intrathecal morphine were infrequent.
    • Tolerance to morphine occurred rarely and was manageable.

    Conclusions:

    • Chronic intrathecal morphine is an effective treatment for intractable cancer pain, supporting previous findings.
    • This technique can also provide satisfactory pain management for carefully selected patients with nonmalignant pain.
    • Implanted intrathecal morphine delivery systems demonstrate a favorable safety and efficacy profile for long-term use.

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