Related Experiment Video
Updated: Aug 31, 2025
08:50
Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
Published on: May 14, 2020
6.8K
Covalent RNA modifications and their budding crosstalk with plant epigenetic processes
Garima Bhatia1, Wil Prall1, Bishwas Sharma1
1Department of Biology, University of Pennsylvania, School of Arts and Sciences, Philadelphia, PA 19104, USA.
Current Opinion in Plant Biology
|August 21, 2022
Summary
Plants utilize epitranscriptomic marks and epigenetic regulation to control gene expression. This study explores the crosstalk between these two layers, revealing insights into plant development and stress responses.
Area of Science:
- Plant molecular biology
- Gene expression regulation
- Epigenetics and epitranscriptomics
Background:
- Diverse RNA modifications (epitranscriptomic marks) in plants offer new insights into gene regulation.
- Epigenetic marks (DNA and histone modifications) are well-studied in plants and impact gene expression.
- Understanding the interplay between the plant epitranscriptome and epigenome is crucial for key biological processes.
Purpose of the Study:
- To investigate the crosstalk between the plant epitranscriptome and epigenetic regulation.
- To explore how these regulatory layers interact to control gene expression.
- To provide insights into plant development and stress response mechanisms.
Main Methods:
- Review of emerging evidence on epitranscriptomic-epigenetic crosstalk.
- Analysis of molecular mechanisms underlying gene expression control.
- Focus on DNA modification, histone modification, and non-coding RNA roles.
Main Results:
- Emerging evidence highlights significant crosstalk between plant epitranscriptomics and epigenetics.
- This interplay intricately determines gene expression levels.
- The interaction influences critical biological processes like development and stress adaptation.
Conclusions:
- The plant epitranscriptome and epigenome are interconnected regulatory layers.
- Crosstalk between these systems is vital for fine-tuning gene expression.
- Further research into this interplay will advance our understanding of plant biology.
Related Concept Videos
01:37Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
02:04Covalently Linked Protein Regulators
7.0K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
7.0K
02:41Chromatin Structure Regulates pre-mRNA Processing
7.1K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.1K
01:53RNA Stability
33.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.8K
02:39lncRNA - Long Non-coding RNAs
8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
01:20Types of RNA
6.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
6.1K