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Updated: Aug 31, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

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Published on: February 2, 2024

Hereditary pancreatic cancer.

Derk C F Klatte¹, Michael B Wallace², Matthias Löhr³

¹Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, United States.

Best Practice & Research. Clinical Gastroenterology

|August 21, 2022

Summary

Early detection of pancreatic cancer is crucial. Hereditary pancreatic cancer surveillance offers benefits but carries risks like overtreatment, necessitating careful management strategies.

Keywords:

Familial pancreatic cancer Hereditary pancreatic cancer High-risk individuals Pancreatic ductal adenocarcinoma Surveillance

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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Published on: April 11, 2025

Area of Science:

Oncology
Genetics
Public Health

Background:

Pancreatic cancer is a highly lethal malignancy with poor survival rates.
Hereditary cancer syndromes significantly increase pancreatic cancer risk.
Early detection through surveillance is vital for improving patient outcomes.

Purpose of the Study:

To review definitions, epidemiology, and risk factors of hereditary pancreatic cancer.
To outline recommendations for genetic testing and surveillance programs.
To discuss surveillance strategies, target lesions, benefits, and harms.

Main Methods:

Literature review of hereditary pancreatic cancer.
Analysis of current genetic testing guidelines.
Evaluation of surveillance program efficacy and risks.

Main Results:

Hereditary factors contribute to a subset of pancreatic cancer cases.
Surveillance programs can improve early detection rates.
Overtreatment and associated risks are significant concerns in surveillance.

Conclusions:

Genetic testing is key for identifying individuals at high risk.
Tailored surveillance strategies are needed to balance benefits and harms.
Future research should focus on optimizing care for high-risk populations.