Fasting and Fasting Mimicking Diets in Obesity and Cardiometabolic Disease Prevention and Treatment
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Updated: Aug 31, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Amrendra Mishra1, Valter D Longo2
1Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Abstract:
Worldwide obesity has risen to record levels generating a major risk factor for metabolic syndrome, diabetes, hypertension, and cardiovascular disease as well as cancer and neurodegenerative diseases. Here we discuss the impact of obesity on lifespan and cardiometabolic disease in mice and humans and how different types of fasting can help prevent and treat them. We argue that specific types of fasting regimens which are associated with low burden, high long-term compliance and safety, can reduce obesity and other disease risk factors, lower morbidity and extend healthspan.
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