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Drug-Induced Liver Injury From Sacubitril-Valsartan Versus a Single Dose of Acarbose
Supraja Achuthanandan1, Amit Dhaliwal1, Ravikaran Patti1
1Internal Medicine, Maimonides Medical Center, Brooklyn, USA.
Abstract:
Numerous known medications can induce liver injury. Sacubitril-valsartan was approved by the Food and Drug Administration in 2015 for use in patients with chronic heart failure to reduce the rate of cardiovascular death and hospitalizations related to heart failure. There are yet to be any reported cases of drug-induced liver injury secondary to sacubitril-valsartan use. Acarbose is well known to be associated with liver failure, but typically liver injury occurs months after initiation of therapy. Here, we report the case of a 76-year-old woman who developed acute liver failure after one month of sacubitril-valsartan use and one day after being prescribed acarbose.
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