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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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The Utility of PTeye in Parathyroidectomy for Recurrent Hyperparathyroidism Due to Intramuscular Parathyroid Autograft Hyperplasia: A Case Report.

Sisli Etfal Hastanesi tip bulteni·2026
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Updated: Aug 31, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
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Primary Hyperparathyroidism with Thyroid Cancer: Clinicopathologic Features.

Selda Gucek Haciyanli1, Serkan Karaisli1, Beste Suataman1

  • 1Department of General Surgery, Izmir Kâtip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.

Sisli Etfal Hastanesi Tip Bulteni
|August 22, 2022
PubMed
Summary

Primary hyperparathyroidism (PHPT) often co-occurs with thyroid disease. Preoperative evaluation is crucial, as current methods, including biopsy, do not reliably detect thyroid cancer in PHPT patients.

Keywords:
Carcinomaparathyroidectomyprimary hyperparathyroidismthyroidthyroidectomy

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Pathology

Background:

  • Primary hyperparathyroidism (PHPT) frequently presents with coexisting thyroid disease, necessitating careful preoperative assessment.
  • Early diagnosis of thyroid carcinoma in PHPT patients is critical for appropriate surgical management.

Purpose of the Study:

  • To investigate clinicopathological features influencing surgical decisions in PHPT patients with concomitant thyroid disease, particularly thyroid cancer.
  • To evaluate the effectiveness of preoperative diagnostics in identifying thyroid malignancy.

Main Methods:

  • Retrospective review of 84 patients undergoing parathyroidectomy with simultaneous thyroidectomy for PHPT.
  • Patients were categorized into benign (Group 1) and malignant (Group 2) thyroid disease based on histopathology.
  • Demographic and clinicopathological characteristics were compared between groups.

Main Results:

  • Thyroid carcinoma was detected in 10.2% of patients undergoing simultaneous thyroidectomy.
  • Total thyroidectomy and complication rates were significantly higher in patients with thyroid cancer (Group 2).
  • Preoperative fine-needle aspiration biopsy had a low detection rate (26.3%) for confirmed thyroid carcinoma.

Conclusions:

  • No definitive preoperative parameter reliably predicts thyroid carcinoma in PHPT patients.
  • A benign biopsy result does not exclude malignancy, potentially leading to missed diagnoses of thyroid cancer, including papillary microcarcinoma.