Related Experiment Video
Updated: Aug 31, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Factors triggering knot formation in ileosigmoid knotting
Ercan Korkut1, Sabri Selcuk Atamanalp2
1Prof. Ercan Korkut, Assist. MD. Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Ileosigmoid knotting (ISK) is a rare condition. Acute diarrhea, harvesting, and overeating are identified as key triggers for ISK, offering insights into its physiopathology.
Area of Science:
- Gastroenterology
- Surgical Pathology
Background:
- Ileosigmoid knotting (ISK) is an uncommon form of double-loop ileus.
- The underlying physiopathology and specific triggering factors of ISK remain poorly understood.
Purpose of the Study:
- To investigate and elucidate the physiopathology of ISK.
- To identify and analyze the primary triggering factors contributing to ISK development.
Main Methods:
- Retrospective and prospective analysis of 80 patients diagnosed with ISK.
- Prospective evaluation of 80 control patients with bowel obstruction due to adhesive ileus or strangulated inguinal hernia.
- Investigation of potential triggers including acute diarrhea, body motions, overeating, coughing, and labor.
Main Results:
- Acute diarrhea was identified as a significant factor in 21.3% of ISK cases (p<0.05).
- Harvesting (e.g., post-operative) was associated with 11.3% of cases (p<0.05).
- Overeating was implicated in 10.0% of ISK cases (p<0.05).
Conclusions:
- Increased bowel motility, excessive body movements, and overeating are suggested as primary triggers for ISK.
- Further research is needed due to limited existing literature on ISK triggers.
Related Concept Videos
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Drugs for Treatment of Constipation-Predominant IBS

