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Primary sulphone resistance. A preliminary report
Leprosy in India
|July 1, 1978
Summary
This study reports a case of lepromatous leprosy resistant to dapsone (DDS). Researchers confirmed DDS resistance by observing continued bacterial growth in mice, prompting further investigation into identifying such resistant leprosy cases.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Dermatology
Background:
- Leprosy, a chronic infectious disease, is typically treated with dapsone (DDS).
- Drug resistance can complicate treatment outcomes and disease management.
- Primary dapsone resistance in leprosy is a significant clinical concern.
Purpose of the Study:
- To report a confirmed case of lepromatous leprosy with primary dapsone (DDS) resistance.
- To describe the methodology used to verify DDS resistance.
- To highlight the need for systematic identification of such resistant cases.
Main Methods:
- A case of lepromatous leprosy was identified and investigated.
- Bacterial resistance to dapsone (DDS) was assessed using a mouse foot pad model.
- Mice were fed a diet containing 0.001% DDS to evaluate bacterial growth.
Main Results:
- The lepromatous leprosy case demonstrated primary resistance to dapsone (DDS).
- Continued growth of leprosy bacilli was observed in the mouse foot pads of DDS-treated mice.
- This confirmed the in vivo resistance to the drug.
Conclusions:
- Primary dapsone (DDS) resistance can occur in lepromatous leprosy.
- The mouse foot pad model is effective in identifying DDS-resistant leprosy bacilli.
- Systematic studies are crucial to identify and manage cases of dapsone-resistant leprosy.