Related Experiment Video
Updated: Aug 31, 2025
07:14
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
Published on: September 20, 2019
8.3K
Centrosome Clustering & Chemotherapy
Farhat Firdous1, Hadeeqa Gull Raza2, Ghayoor Abbas Chotana1
1Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, 54792, Pakistan.
Mini Reviews in Medicinal Chemistry
|August 22, 2022
Summary
Cancer cells survive with extra centrosomes using clustering. Inhibiting this process, or declustering centrosomes, offers a promising strategy to selectively eliminate cancer cells by targeting their unique survival mechanisms.
Area of Science:
- Cell Biology
- Cancer Biology
- Molecular Oncology
Background:
- Centrosome abnormalities are a key feature of cancer, often leading to chromosomal instability and tumorigenesis.
- Cancer cells develop mechanisms to survive chromosomal instability, unlike normal cells which undergo apoptosis.
- Centrosome clustering is a primary mechanism enabling cancer cells with supernumerary centrosomes to divide.
Conclusions:
- Targeting centrosome clustering offers a selective approach to eliminate cancer cells.
- De-clustering of supernumerary centrosomes is a promising anti-cancer therapeutic strategy.
- Further research into centrosome declustering agents is warranted for cancer treatment.
Keywords:
Cancercentrosome amplificationcentrosome clusteringcentrosome de-clustering agentscentrosome duplication cyclechemotherapychromosomal instabilitymultipolarityMore Related Videos
Related Concept Videos
02:25Centrosome Duplication
4.1K
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
4.1K
01:13Centrioles and Centrosomes
3.1K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
Near the end of the prophase, also called late prophase or...
3.1K
01:15Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
01:10Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K
01:45Destabilization of Microtubules
2.8K
The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
2.8K
02:17Separation of Sister Chromatids
3.8K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.8K