Related Experiment Video
Updated: Aug 31, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Precision medicine in type 1 diabetes.
Alice L J Carr1, Carmella Evans-Molina2,3,4,5,6,7,8, Richard A Oram9
1Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. aljc201@exeter.ac.uk.
Personalized care for type 1 diabetes has evolved significantly over 100 years, moving towards tailored insulin therapy and management. Advances in understanding autoimmunity and technology are driving precision medicine for better diabetes outcomes.
Area of Science:
- Endocrinology
- Immunology
- Genetics
Background:
- The historical goal of person-centred diabetes care aimed to individualize insulin therapy.
- Type 1 diabetes (T1D) is now recognized as an autoimmune disease, advancing care strategies.
- Significant progress in understanding T1D pathophysiology, genetics, and natural history has been achieved.
Purpose of the Study:
- To review the evolution of personalized approaches in type 1 diabetes care.
- To discuss how personalized strategies have improved diagnosis, treatment, prevention, and prediction.
- To explore future directions for precision medicine in T1D.
Main Methods:
- Literature review of personalized approaches in type 1 diabetes.
- Analysis of advancements in understanding T1D pathogenesis and human biology.
- Examination of technological progress in insulin delivery and glucose monitoring.
Main Results:
- Personalized approaches have enhanced type 1 diabetes management over the past century.
- Recognition of T1D as autoimmune has been crucial for developing targeted therapies.
- Technological innovations support improved self-management and individualized treatment.
Conclusions:
- Personalized medicine in type 1 diabetes has transformed patient care.
- Future understanding of pathogenesis and biology will further refine precision medicine.
- Continued integration of research and technology promises improved T1D outcomes.
More Related Videos
08:16Author Spotlight: Advancing Type 1 Diabetes Research Using Innovative Pancreatic Slice Platforms
Published on: March 15, 2024
11:31High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Diabetes Mellitus: Type 2 and Gestational
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes: Symptoms, Diagnosis, and Complications
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...