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A Review of Cardiac Amyloidosis: Presentation, Diagnosis, and Treatment

Issa Pour-Ghaz1, Anandbir Bath1, Sharif Kayali1

  • 1Department of Internal Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN.

Current Problems in Cardiology
|August 22, 2022
PubMed

Insights

Cardiac amyloidosis, a heart condition from protein misfolding, presents diverse symptoms and is often diagnosed late. Newer methods improve early detection and treatment, offering hope for patients.

Area of Science:

  • Cardiology
  • Pathology
  • Medical Diagnostics

Background:

  • Amyloidosis involves protein misfolding and deposition in organs.
  • Cardiac amyloidosis presents with varied symptoms like heart failure and arrhythmias.
  • Delayed diagnosis of cardiac amyloidosis leads to high morbidity and mortality.

Purpose of the Study:

  • To review the pathology, diagnosis, and treatment of cardiac amyloidosis.
  • To highlight the challenges in diagnosing cardiac amyloidosis.
  • To discuss advancements aiding early diagnosis and treatment.

Main Methods:

  • Review of existing literature on cardiac amyloidosis.
  • Discussion of diagnostic challenges and newer imaging modalities.
  • Overview of current and emerging treatment options.

Main Results:

  • Cardiac amyloidosis has diverse clinical presentations.
  • Early diagnosis is often delayed due to non-specific symptoms.
  • Advanced imaging and biomarkers enhance diagnostic feasibility.
  • Various treatment options offer improved patient outcomes.

Conclusions:

  • Cardiac amyloidosis is a complex condition requiring timely diagnosis.
  • Advancements in diagnostics and therapeutics are improving patient prognosis.
  • Comprehensive understanding aids in managing this disease.

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