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04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.1K
Perceived Cognitive Function in People With Systemic Sclerosis: Associations With Symptoms and Daily Life Functioning
Yen T Chen1, Alain Lescoat2, Dinesh Khanna1
1University of Michigan, Ann Arbor.
Arthritis Care & Research
|August 23, 2022
Summary
Systemic sclerosis patients often report cognitive issues. Work disability and fatigue strongly link to these perceived cognitive problems, not independent function.
Area of Science:
- Rheumatology
- Neuropsychology
- Patient-Reported Outcomes
Background:
- Perceived cognitive dysfunction is common in systemic sclerosis (SSc) but its underlying factors and impact remain unclear.
- Understanding cognitive dysfunction is crucial for improving patient quality of life in SSc.
Purpose of the Study:
- To identify factors associated with perceived cognitive function in SSc patients.
- To determine the independent contributions of perceived cognitive function and other symptoms to functional measures in SSc.
Main Methods:
- A cross-sectional survey of 106 SSc patients.
- Assessment of perceived cognitive function, symptoms, and functional measures using Patient-Reported Outcomes Measurement Information System (PROMIS).
- Multivariable and hierarchical linear regression analyses were employed.
Main Results:
- Over half (56%) of SSc patients reported mild-to-severe cognitive dysfunction.
- Work disability and increased fatigue were significantly associated with perceived cognitive dysfunction.
- Perceived cognitive function lost its independent association with functional measures when fatigue and pain were included in the model.
Conclusions:
- Work disability and fatigue are key factors associated with perceived cognitive dysfunction in SSc.
- Perceived cognitive function is not an independent predictor of functional measures in SSc, unlike fatigue and pain.
- Further research is needed to differentiate the effects of cognitive function and other symptoms on daily activities in SSc.
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