Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

404
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
404
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

190
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
190
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

626
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
626
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

2.9K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
2.9K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

415
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
415

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk assessment and mitigation of hepatitis C virus RNA carryover contamination in a reflex testing algorithm.

Journal of clinical microbiology·2026
Same author

Perioperative Prophylaxis in Pediatric Solid Organ Transplantation: A Baseline Stewardship Audit Using Routine Electronic Data.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

A diagnostic gap in rising Lyme borreliosis endemicity: Lyme testing patterns among facial palsy patients in Ohio, 2022-2024.

Diagnostic microbiology and infectious disease·2026
Same author

The first case of Teclistamab interference with serum electrophoresis and immunofixation.

Clinical chemistry and laboratory medicine·2026
Same author

The Prevalence of Alpha-Gal IgE among Patients with Confirmed Lyme Serology Result.

International archives of allergy and immunology·2026
Same author

When Polymerase Chain Reaction Positivity Is Not Disease: Implications for Clostridioides difficile Vaccine Trial Endpoints.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Measles-Associated Stridor.

Pediatrics·2026
Same journal

MTHFR, Pneumonia, and Thrombosis in Children: A Gene-Infection Interaction.

Pediatrics·2026
Same journal

Early Adulthood Outcomes Among Individuals With Neurologic Impairment and Technology Assistance.

Pediatrics·2026
Same journal

Video vs Telephone Consultations for Pediatric Quality of Care in Emergency Departments.

Pediatrics·2026
Same journal

A Resource to Understand and Prevent Sudden Unexpected Infant Deaths.

Pediatrics·2026
Same journal

Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016-2025.

Pediatrics·2026
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

4.0K

Outcomes After Positive Syphilis Screening.

Nicola P O'Connor1, Patrick C Burke2, Sarah Worley3

  • 1Center for Pediatric Infectious Diseases, Cleveland Clinic Children's, Cleveland, Ohio.

Pediatrics
|August 24, 2022
PubMed
Summary
This summary is machine-generated.

Syphilis screening in pregnancy has a high false discovery rate, leading to unnecessary treatment and potential gaps in care. This can increase the risk of congenital syphilis despite screening efforts.

More Related Videos

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
07:54

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

2.5K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K

Related Experiment Videos

Last Updated: Aug 31, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
09:45

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

Published on: January 24, 2025

4.0K
Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test
07:54

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

2.5K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K

Area of Science:

  • Maternal and Child Health
  • Infectious Disease Epidemiology
  • Clinical Diagnostics

Background:

  • Syphilis screening during pregnancy is crucial for preventing congenital syphilis.
  • The impact of false positive (FP) screens and the effectiveness of treatment following screening are not well understood.

Purpose of the Study:

  • To determine the false discovery rate of syphilis screening in pregnant populations.
  • To evaluate the consequences of FP screens, including unnecessary treatment.
  • To assess treatment adherence and outcomes for mothers and infants identified with syphilis.

Main Methods:

  • Analysis of 75,056 pregnancies using laboratory criteria to classify syphilis screens as FP or true positive (TP).
  • Calculation of false discovery rates for different screening algorithms and assays.
  • Determination of treatment, clinical characteristics, and syphilis classifications for mothers and infants.

Main Results:

  • A high false discovery rate of 0.83 was observed for syphilis screening.
  • FP screens resulted in unnecessary treatment for 3 individuals (2 mothers, 1 infant).
  • Congenital syphilis occurred in one infant due to delayed diagnosis and inadequate follow-up in a high-risk mother.

Conclusions:

  • Syphilis screening limitations include a high FP rate leading to overtreatment.
  • Inconsistent risk-based rescreening and suboptimal care for TP mothers can increase congenital syphilis risk.
  • Improved management strategies are needed to optimize care and prevent adverse infant outcomes.