Related Experiment Video
Updated: Aug 31, 2025

A High-Yield Streptomyces Transcription-Translation Toolkit for Synthetic Biology and Natural Product Applications
Published on: September 10, 2021
Streptothiazolidine B, a new cytotoxic alkaloid produced by Streptomyces violaceoruber
Tao Wang1,2, Da-Wei Kang1, Dong-Bao Hu3
1School of Medicine, Kunming University, Kunming 650214, China.
Abstract:
A new cytotoxic alkaloid, named streptothiazolidine B (1), together with three known compounds (2-4), were isolated from Streptomyces violaceoruber. The structure of the undescribed compound was established using 1D and 2D NMR, and HRESIMS. Streptothiazolidine B was isolated and identified as an amide alkaloid with a unique thiazolidine side chain and its absolute configuration was determined by a combination of NOESY experiment and ECD analysis. Streptothiazolidine B exhibited significant cytotoxic activities against two human tumor cell lines, Li-7 and A2780, with IC50 values of 7.8, and 9.1 μM. Meanwhile, compound 4 showed obvious cytotoxic activities against four human tumor cell lines, THP-1, HT29, Li-7 and A2780, with IC50 values ranging from 3.1 to 10.2 μM.
More Related Videos
09:08From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
07:23Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
Published on: August 8, 2025
Related Concept Videos
Drugs that Destabilize Microtubules
Bacterial Phylum Actinobacteria
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Bacterial Phylum Planctomycetes
Drugs that Stabilize Microtubules