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The E-Id axis specifies adaptive and innate lymphoid lineage cell fates

Masaki Miyazaki1, Kazuko Miyazaki1

  • 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, 606-8507, Kyoto, Japan.

Journal of Biochemistry
|August 24, 2022
PubMed
Summary

Adaptive immunity relies on V(D)J recombination, a process involving recombination activation gene (Rag) 1/2 proteins. This review explores how Rag gene expression guides adaptive lymphocyte lineage commitment and differentiates them from innate lymphoid cells.

Keywords:
E2ARag1/Rag2 expressionT and B cell developmentadaptive immunitygene regulaton

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