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The Function of E2A in B-Cell Development

Masaki Miyazaki1, Kazuko Miyazaki2

  • 1Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. mmiyazaki@infront.kyoto-u.ac.jp.

Advances in Experimental Medicine and Biology
|July 17, 2024
PubMed
Summary

E2A transcription factors are crucial for B-cell development, orchestrating gene expression by forming super-enhancers. This process involves recruiting key proteins to regulate chromatin structure and gene activation.

Keywords:
Adaptive lymphocyteB-cell developmentBasic-helix-loop-helix transcription factorE2AEnhancer regulationRag1 and Rag2 expression

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