Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Endovascular Therapy for Intracranial Atherosclerotic Stenosis: Evidence and Controversies.

Journal of neuroendovascular therapy·2026

Same author

Stroke Scales for Large Vessel Occlusion in the Prehospital Emergency Setting: A Systematic Review and Meta-Analysis.

Journal of the American Heart Association·2026

Same author

The Thrombectomy Dilemma in Stroke Patients With Active Cancer: To Treat or Not to Treat?

Journal of stroke·2026

Same author

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact.

Stroke·2026

Same author

Impact of Intracranial Atherosclerosis and Cerebral Small Vessel Disease on Overt Vascular Events During Antithrombotic Therapy.

European journal of neurology·2026

Same author

Feasibility and Safety of a Computer-Controlled Device for Transradial Cerebral Angiography: A Prospective Pilot Study.

Journal of neuroendovascular therapy·2026

Search research articles

Related Experiment Video

Updated: Aug 31, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial.

Kentaro Ishizuka¹, Takao Hoshino¹, Sono Toi¹

¹Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.

Frontiers in Neurology

|August 25, 2022

Summary

This summary is machine-generated.

Remote ischemic conditioning (RIC) may improve outcomes for stroke patients. This clinical trial investigates RIC

Keywords:

acute ischemic stroke good functional outcome neurological severity randomized controlled trial remote ischemic conditioning (RIC)

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

Related Experiment Videos

Last Updated: Aug 31, 2025

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Author Spotlight: Establishing a Reliable Distal MCA Occlusion Model in Mice for Stroke Research

Published on: December 15, 2023

Area of Science:

Neurology
Cardiovascular Medicine
Regenerative Medicine

Background:

Remote ischemic conditioning (RIC) involves brief, repeated ischemia to protect distant tissues from prolonged ischemic damage.
Ischemic stroke remains a leading cause of disability, necessitating novel therapeutic strategies.

Purpose of the Study:

To evaluate the efficacy of RIC in improving functional outcomes for patients following ischemic stroke.
To determine if RIC can be recommended as a standard clinical intervention for stroke patients.

Main Methods:

A multicenter, prospective, randomized, open-label trial involving 400 patients with ischemic stroke.
Patients were stratified into mild, moderate, and severe groups based on NIH Stroke Scale scores.
The intervention group received four cycles of RIC using a thigh cuff, while the control group received sham intervention.

Main Results:

The primary outcome is functional outcome measured by the modified Rankin Scale (mRS) at 90 days post-stroke.
Specific target mRS scores (0-1 for mild, 0-2 for moderate, 0-3 for severe) define a good functional outcome.

Conclusions:

This trial aims to provide crucial evidence on the clinical utility of RIC for ischemic stroke.
Findings will inform guidelines regarding the adoption of RIC as a routine stroke management strategy.