Related Experiment Video

Updated: Aug 31, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.4K

Risk Factors for Calcific Aortic Valve Disease in Afghan Population

Abdul Ghafar Sherzad1,2, Muhibullah Shinwari3, M Azim Azimee2

  • 1Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Vascular Health and Risk Management
|August 25, 2022
PubMed

Insights

Calcific aortic valve disease (CAVD) risk factors in Afghans include sedentary lifestyle, diabetes mellitus, high BMI, good socioeconomic status, and hypertension. These factors are linked to CAVD development, not just aging.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Calcific aortic valve disease (CAVD) is increasingly recognized as a significant health issue.
  • While aging is a known factor, specific risk factors for CAVD are not fully understood, particularly in diverse populations.
  • Previous research indicates CAVD may be influenced by specific risk factors beyond aging.

Purpose of the Study:

  • To identify the clinical features of CAVD in the Afghan population.
  • To determine independent risk factors associated with CAVD in this demographic.
  • To contribute to a better understanding of CAVD epidemiology in South Asia.

Main Methods:

  • A case-control study involving 1072 Afghan participants (age >18 years) was conducted from January 2018 to December 2020.
  • Participants were categorized into two groups: 536 with CAVD and 536 age- and sex-matched controls, based on echocardiographic findings.
  • Multivariate logistic regression analysis was employed to identify independent predictors of CAVD using data from medical records and questionnaires.

Main Results:

  • The study identified several independent risk factors for CAVD in the Afghan population.
  • These include a sedentary lifestyle (OR=2.517), diabetes mellitus (OR=1.902), high body mass index (BMI ≥ 30 kg/m²; OR=1.776), good socioeconomic status (OR=1.724), and hypertension (OR=1.664).
  • Aortic valve stenosis, aortic valve calcification, and bicuspid aortic valve were observed among CAVD patients.

Conclusions:

  • Sedentary lifestyle, diabetes mellitus, high BMI, good socioeconomic status, and hypertension are significant independent risk factors for CAVD in the Afghan population.
  • These findings suggest that CAVD is not solely an age-related condition and can be influenced by modifiable lifestyle and health factors.
  • The study highlights the need for targeted interventions and awareness programs for CAVD prevention in this population.
Abstract

Keywords:
aortic valve calcificationaortic valve sclerosisaortic valve stenosisindependent risk factorsrisk factors for atherosclerosis

More Related Videos

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.1K
Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.7K

Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
24
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
111
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
47
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
47
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
33
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
30