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Liquid Crystal Biosensors: Principles, Structure and Applications.

Haonan Wang¹, Tianhua Xu^1,2, Yaoxin Fu¹

¹School of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China.

|August 25, 2022

Summary

This summary is machine-generated.

Liquid crystal (LC) biosensors leverage biomolecular binding to alter LC orientation for detection. Combining LCs with whispering gallery mode (WGM) microcavities enhances sensitivity for advanced biological sensing applications.

Keywords:

LC-based biosensors liquid crystals microfluidics optofluidic whispering gallery mode

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Area of Science:

Biomolecular Sensing
Optofluidics
Materials Science

Background:

Liquid crystals (LCs) are utilized as sensitive elements in biosensors.
Biomolecular interactions alter LC orientation, forming the basis for detection.
LC biosensors are classified by their sensing interface: LC-solid, LC-aqueous, and LC-droplet.

Purpose of the Study:

To provide a comprehensive overview of LC biosensors.
To discuss the principles, structures, and applications of LC biosensors.
To explore the integration of LCs with whispering gallery mode (WGM) optical microcavities for enhanced sensitivity.

Main Methods:

Review of LC properties and biosensing principles.
Description of various LC geometries in biosensing systems.
Introduction to LC-based WGM microcavity optofluidic sensors.

Main Results:

LC biosensors offer diverse sensing platforms based on interface types.
LCs combined with WGM microcavities significantly enhance detection sensitivity.
Applications span various biological detection scenarios.

Conclusions:

LC biosensors represent a promising technology for sensitive biological detection.
Integration with WGM microcavities offers a pathway to highly sensitive optofluidic sensors.
Future research opportunities exist in advancing LC biosensor development.