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Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

Xiaojun Ju1, Piotr Gaca1, Wanlin Fan1

  • 1Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Neuro-Signals
|August 25, 2022
PubMed

Insights

Eyelid and ocular surface tumors often recur after surgery. This review explores recurrence, metastasis, and drug resistance mechanisms to improve cancer treatment outcomes.

Area of Science:

  • Ophthalmology
  • Oncology
  • Cancer Biology

Background:

  • Malignant tumors of the eyelids and ocular surface are common ocular malignancies.
  • Surgical treatment is the primary approach, but recurrence and metastasis remain significant challenges.
  • Adjuvant and systemic chemotherapy are used for advanced cases, yet drug resistance limits efficacy.

Purpose of the Study:

  • To review the mechanisms of recurrence and metastasis in eyelid and ocular surface tumors post-surgery.
  • To explore factors contributing to non-surgical treatment failure and drug resistance.

Main Methods:

  • Literature review of studies on ocular surface and eyelid malignancies.
  • Analysis of mechanisms underlying tumor recurrence, metastasis, and drug resistance.
  • Synthesis of current understanding of treatment challenges.

Main Results:

  • Identified key pathways and factors driving tumor recurrence and metastasis after surgical resection.
  • Highlighted cellular and molecular mechanisms contributing to chemotherapy resistance.
  • Discussed challenges in achieving successful non-surgical treatment outcomes.

Conclusions:

  • Understanding recurrence, metastasis, and drug resistance mechanisms is crucial for improving treatment strategies.
  • Further research into novel therapeutic targets and combination therapies is warranted.
  • Developing strategies to overcome drug resistance is essential for enhancing patient survival and quality of life.
Keywords:
Periocular basal cell carcinoma; Squamous cell carcinoma; Sebaceous gland carcinoma; Conjunctival melanoma; Ocular surface squamous neoplasia; Therapeutics; Drug resistance

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