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Updated: Aug 31, 2025
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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Cardiovascular Mortality Risk in Patients with Bladder Cancer: A Population-Based Study
Shunde Wang1, Chengguo Ge2, Junyong Zhang2
1Department of Urology, The ChenJiaqiao Hospital of ShaPingba District of Chongqing City, Chongqing 401331, China.
Journal of Cardiovascular Development and Disease
|August 25, 2022
Summary
Patients with bladder cancer (BC) face a higher risk of cardiovascular mortality (CVM) than the general population. Identifying high-risk BC patients can improve survival through targeted cardiovascular interventions.
Area of Science:
- Oncology
- Cardiovascular Epidemiology
- Public Health
Background:
- Bladder cancer (BC) is a significant public health concern.
- Cardiovascular mortality (CVM) is a leading cause of death globally.
- The relationship between BC and CVM requires further investigation.
Purpose of the Study:
- To evaluate the risk of cardiovascular mortality (CVM) in patients diagnosed with bladder cancer (BC).
- To identify predictors of CVM in the BC patient cohort.
Main Methods:
- Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2016).
- Calculated standardized mortality rates (SMR) against the general population.
- Employed Nelson-Aalen cumulative hazard curves and multivariate competing risk models.
Main Results:
- Analyzed data from 237,563 BC patients; 21,822 experienced CVM.
- Overall SMR for CVM in BC patients was 1.16 (95% CI: 1.14-1.17).
- Independent predictors of CVM included age, race, sex, diagnosis year, histology, stage, surgery, marital status, and education.
Conclusions:
- Bladder cancer patients exhibit a significantly elevated risk of cardiovascular mortality.
- Proactive identification of high-risk individuals and cardiovascular protection strategies are crucial for enhancing survival rates in BC patients.
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