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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Competing Risk Analysis for Diabetes Mellitus Mortality in Bladder Cancer Patients: A Population-based Study
Shunde Wang1, Baishu Zheng2, Junjie Yang1
1Department of Urology, The ChenJiaqiao Hospital of ShaPingba District of Chongqing city, Chongqing, 401331, China.
Current Cancer Drug Targets
|March 7, 2025
Summary
Patients with bladder cancer (BC) face a significantly higher risk of death from diabetes mellitus (DM). Advanced age, male sex, and certain cancer characteristics increase this risk, highlighting the need for targeted interventions.
Area of Science:
- Oncology
- Endocrinology
- Public Health
Background:
- Limited focus on mortality rates for individuals with concurrent diabetes and bladder cancer (BC).
- Need to identify risk factors for death from diabetes mellitus (DM) specifically within the BC patient population.
Purpose of the Study:
- To determine the mortality rate of DM in BC patients.
- To identify risk factors associated with DM mortality in individuals diagnosed with BC.
Main Methods:
- Utilized SEER database for BC patients diagnosed between 2000-2017.
- Calculated Standardized Mortality Ratio (SMR) for DM mortality.
- Employed a multivariate competing risk model to identify risk factors, using Hazard Ratios (HR) and 95% Confidence Intervals (95% CI).
Main Results:
- Analyzed data from 217,230 BC patients; 1,783 experienced DM mortality.
- Overall SMR for DM mortality in BC patients was 3.32 (95% CI: 3.17-3.48).
- Higher risk of DM mortality associated with advanced age, male sex, Black race, in situ tumor stage, early diagnosis year, transitional cell carcinoma, no chemotherapy/radiation, and lack of spouse.
Conclusions:
- Individuals with BC have a substantially elevated risk of DM mortality compared to the general population.
- Identifying high-risk groups is crucial for implementing targeted DM interventions.
- Effective interventions can improve survival rates for BC patients with diabetes.
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